Rr696751^em1Jkm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr696751^em1Jkm
• Name: regulatory region 696751; endonuclease-mediated mutation 1, Jin Woo Kim
• MGI ID: MGI:6203122
• Synonyms: Pax6^deltaPBS, Pax6^em1Jkm
• Gene: Rr696751 Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Rr696751^em1Jkm page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 6bp deletion (GRCm39:chr2:105512710-105512715delTGCATG) in the auto-regulatory Pax6 binding sequence of the retina-specific alpha enhancer in intron 4. (J:240931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr696751 Mutation: 0 strains or lines available

References

• Original: J:240931 Kim Y, et al., The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity. Elife. 2017 Jan 31;6:e21303
• All: 1 reference(s)