Mapkapk2^tm2.1Yaff
Targeted Allele Detail

Summary

• Symbol: Mapkapk2^tm2.1Yaff
• Name: MAP kinase-activated protein kinase 2; targeted mutation 2.1, Michael Yaffe
• MGI ID: MGI:6203066
• Synonyms: MK2^FL
• Gene: Mapkapk2 Location: Chr1:130981437-131025563 bp, - strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Mapkapk2^tm2.1Yaff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261657
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed and the 5' loxP site is in reverse complement sequence to the 3' loxP site. Flp-mediated recombination removed the selection cassette inserted downstream of the loxP site inserted into intron 2. (J:261657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapkapk2 Mutation: 36 strains or lines available

References

• Original: J:261657 Suarez-Lopez L, et al., MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4236-E4244
• All: 2 reference(s)