Gt(ROSA)26Sor^{tm1(CAG-Pgr)Lyd}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Pgr)Lyd}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, John P Lydon
• MGI ID: MGI:6202712
• Synonyms: Pgr-B^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Pgr)Lyd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265806
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Pgr)Lyd} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pgr (MGI:97567)	isoform B specific and 5' FLAG tagged mouse cDNA preceded by an LSL cassette

• Mutation details: The inserted construct comprises the following elements: the CAG (chicken beta-actin promoter and cytomegalovirus (CMV) enhancer) promoter, a loxP site flanked STOP cassette, sequences for a FLAG tag ligated in-frame to the isoform B specific mouse cDNA coding region, and rabbit beta-globin poly(A) signal sequences. (J:265806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:265806 Hai L, et al., A mouse model engineered to conditionally express the progesterone receptor-B isoform. Genesis. 2018 Aug;56(8):e23223
• All: 3 reference(s)