Igf2bp2^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Igf2bp2^tm1.1Thor
• Name: insulin-like growth factor 2 mRNA binding protein 2; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:6202514
• Synonyms: Imp2^fl
• Gene: Igf2bp2 Location: Chr16:21877759-21982049 bp, - strand Genetic Position: Chr16, 13.02 cM
• Alliance: Igf2bp2^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked neomycin selection cassette and a loxP site inserted downstream of exon 5 of the targeted gene, and another loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 4 through 5 floxed. (J:235757)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igf2bp2 Mutation: 89 strains or lines available

References

• Original: J:235757 Degrauwe N, et al., The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Rep. 2016 May 24;15(8):1634-47
• All: 3 reference(s)