Rara^tm1Kwki
Targeted Allele Detail

Summary

• Symbol: Rara^tm1Kwki
• Name: retinoic acid receptor, alpha; targeted mutation 1, Kwanhee Kim
• MGI ID: MGI:6202123
• Synonyms: Rara^fl
• Gene: Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
• Alliance: Rara^tm1Kwki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265691
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and a neomycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 4. This creates a conditional-ready allele with exon 4 (coding for part of the B domain) floxed. (J:265691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rara Mutation: 80 strains or lines available

References

• Original: J:265691 Peer NR, et al., Germ Cell-Specific Retinoic Acid Receptor alpha Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia. Endocrinology. 2018 Sep 1;159(9):3403-3420
• All: 1 reference(s)