Trp53^tm1.1Hwan
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Hwan
• Name: transformation related protein 53; targeted mutation 1.1, Paul M Hwang
• MGI ID: MGI:6202103
• Synonyms: p53^334H
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Hwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265556
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A G-to-A mutation in exon 10 (c.1001G>A), resulting in an arginine to histidine substitution at amino acid position 334 (p.R334H), and a loxP site flanked neomycin resistance gene cassette were inserted via homologous recombination. Cre-mediated recombination removed the neo cassette. (J:265556)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.1Hwan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:265556 Park JH, et al., Mouse Homolog of the Human TP53 R337H Mutation Reveals Its Role in Tumorigenesis. Cancer Res. 2018 Sep 15;78(18):5375-5383
• All: 1 reference(s)