Rag1^em1Ldn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rag1^em1Ldn
• Name: recombination activating 1; endonuclease-mediated mutation 1, Luigi D Notarangelo
• MGI ID: MGI:6202078
• Synonyms: Rag1^H836Q
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^em1Ldn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (No functional change)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination induced a T to A mutation at position 2508 (c.2508T>A) resulting in a histidine 836 glutamine missense mutation. (J:265589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 133 strains or lines available

References

• Original: J:265589 Ott de Bruin L, et al., Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes. Oncotarget. 2016 Mar 15;7(11):12962-74
• All: 1 reference(s)