Pdgfra^{tm1.1(cre/ERT2)Blh}
Targeted Allele Detail

Summary

• Symbol: Pdgfra^{tm1.1(cre/ERT2)Blh}
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Brigid L Hogan
• MGI ID: MGI:6201731
• Synonyms: Pdgfra-CreER^T2
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^{tm1.1(cre/ERT2)Blh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263983
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pdgfra^{tm1.1(cre/ERT2)Blh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfra (MGI:97530)

• Mutation details: The targeting vector contained an cre/ERT2 cassette inserted at the start codon of the Pdgfra locus. The cre cassette was followed by a FRT-flanked neo cassette, which was removed by flp-mediated excision after germline transmission. (J:263983)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfra (mouse) Summary of all recombinase alleles driven by Pdgfra. Comparative matrix view of recombinase activities Alliance mouse Pdgfra gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 85 strains or lines available

References

• Original: J:263983 Chung MI, et al., Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation. Development. 2018 May 11;145(9):dev163014
• All: 24 reference(s)