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Targeted Allele Detail
Symbol: Grptm1.1(icre)Himo
Name: gastrin releasing peptide; targeted mutation 1.1, Hisashi Mori
MGI ID: MGI:6201709
Synonyms: Grp-iCre
Gene: Grp  Location: Chr18:66005891-66019667 bp, + strand  Genetic Position: Chr18, 38.98 cM
Alliance: Grptm1.1(icre)Himo page
Germline Transmission:  Earliest citation of germline transmission: J:264153
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Grptm1.1(icre)Himo expression driven by 1 gene
Mutation detailsiCre and FRT flanked pgk-neo cassettes were inserted into the gastrin-releasing peptide gene (Grp) locus translation initiation site by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)
 Tissue activity of this recombinase allele
Driver: Grp (mouse)
Summary of all recombinase alleles driven by Grp.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grp Mutation:  30 strains or lines available
Original:  J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory