Crh^tm1.1Jde
Targeted Allele Detail

Summary

• Symbol: Crh^tm1.1Jde
• Name: corticotropin releasing hormone; targeted mutation 1.1, Jan Deussing
• MGI ID: MGI:6201415
• Synonyms: Crh^flox
• Gene: Crh Location: Chr3:19747565-19749560 bp, - strand Genetic Position: Chr3, 5.75 cM
• Alliance: Crh^tm1.1Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264526
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Flp-mediated recombination of Crh^tm1Jde removes the reporter and neo cassettes and left exon 2 coding sequence floxed. (J:264526)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crh Mutation: 42 strains or lines available

References

• Original: J:264526 Dedic N, et al., Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 Jun;21(6):803-807
• All: 2 reference(s)