Tg(tetO-STS)#Wexi
Transgene Detail

Summary

• Symbol: Tg(tetO-STS)#Wexi
• Name: transgene insertion, Wen Xie
• MGI ID: MGI:6201410
• Synonyms: TRE-STS
• Transgene: Tg(tetO-STS)#Wexi Location: unknown
• Alliance: Tg(tetO-STS)#Wexi page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-STS)#Wexi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STS (412)

  Sts	(MGI:98438)

  inducible; human cDNA

• Mutation details: The human steroid sulfatase cDNA (with added HA tag sequences) is driven by tetracycline response elements (TRE) and a minimal CMV promoter. Downstream of the cDNA are SV40 poly(A) signal sequences. The gene is only expressed in a tetracycline/doxycycline controllable manner if mice containing this allele are crossed with mice containing a tTA or rtTA allele. (J:211206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:211206 Jiang M, et al., Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. J Biol Chem. 2014 Mar 21;289(12):8086-97
• All: 3 reference(s)