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Transgene Detail
Symbol: Tg(Ntrk2-cre/ERT2)#Phep
Name: transgene insertion, Paul A Heppenstall
MGI ID: MGI:6201344
Synonyms: TrkBCreERT2
Transgene: Tg(Ntrk2-cre/ERT2)#Phep  Location: unknown  
Alliance: Tg(Ntrk2-cre/ERT2)#Phep page
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Tg(Ntrk2-cre/ERT2)#Phep expression driven by 1 gene
Mutation detailsA cassette containing a modified CreERT2-pA-Frt-Ampicillin-Frt was inserted in the first coding ATG of exon 2 into a bacterial artificial chromosome (BAC) containing the Ntrk2 mouse locus (RP23-391J8) deleting the entire coding region of exon 2. Purified BAC cDNA was purified and injected into pronuclei of B6D2F1/N oocytes or prepared for intracytoplasmic sperm injection (ICSI). Both methods produced transgenic offspring. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:265202)
 Tissue activity of this recombinase allele
Driver: Ntrk2 (mouse)
Summary of all recombinase alleles driven by Ntrk2.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:265202 Dhandapani R, et al., Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. 2018 Apr 24;9(1):1640
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
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