Tg(tetO-SLC33A1)1Lpu
Transgene Detail

Summary

• Symbol: Tg(tetO-SLC33A1)1Lpu
• Name: transgene insertion 1, Luigi Puglielli
• MGI ID: MGI:6201208
• Synonyms: pTRE-AT-1
• Transgene: Tg(tetO-SLC33A1)1Lpu Location: unknown
• Alliance: Tg(tetO-SLC33A1)1Lpu page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-SLC33A1)1Lpu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SLC33A1 (9197)

  Slc33a1

  (MGI:1332247)

  inducible; human cDNA

• Mutation details: The construct contains the human cDNA under the control of tetracycline response elements. The exogenous gene will only be expressed, in a tetracycline/doxycycline-inducible manner, if mice carrying this allele also carry a tTA or rtTA allele. (J:236112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:236112 Hullinger R, et al., Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation. J Exp Med. 2016 Jun 27;213(7):1267-84
• All: 8 reference(s)