Arhgap4^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgap4^em1(IMPC)J
• Name: Rho GTPase activating protein 4; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6201201
• Gene: Arhgap4 Location: ChrX:72937958-72954945 bp, - strand Genetic Position: ChrX, 37.45 cM
• Alliance: Arhgap4^em1(IMPC)J page
• IMPC: Arhgap4 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 4 guide sequences CTTAGTCATGACCTTCAGCA, TGTCTGCCCGCCCTAAACCA, ATTTCAGATCTGAATCTTGG and TCAGAAGCCCCTGTGCACTT, which resulted in a 1177 bp deletion beginning at Chromosome X position 73,905,895 bp and ending after 73,907,071 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001242137, ENSMUSE00001255499, ENSMUSE00001218299 (exons 2-4) and 743 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 22 and early truncation 15 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Arhgap4 Mutation: 13 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)