Trpa1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Trpa1^m1Btlr
• Name: transient receptor potential cation channel, subfamily A, member 1; mutation 1, Bruce Beutler
• MGI ID: MGI:6199997
• Gene: Trpa1 Location: Chr1:14942872-14989086 bp, - strand Genetic Position: Chr1, 4.5 cM
• Alliance: Trpa1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 14,891,303 (v38) on chromosome 1, or base pair 27,712 in the GenBank genomic region NC_000067 within the donor splice site of intron 15. The mutation is predicted to result in skipping of the 94-nucleotide exon 15 (out of 27 total exons), resulting in a frame-shifted protein product beginning after amino acid 605, and termination after the inclusion of two aberrant amino acids. (J:262266)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpa1 Mutation: 92 strains or lines available

References

• Original: J:262266 Wang Y, et al., Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun. 2018 May 23;9(1):2041
• All: 1 reference(s)