Ptprc^M5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^M5Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 5, Bruce Beutler
• MGI ID: MGI:6199958
• Synonyms: Half-measure
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^M5Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 138,071,249 (v38) on chromosome 1, or base pair 104,508 in the GenBank genomic region NC_000067 encoding Ptprc. The mutation corresponds to residue 3,101 in the mRNA sequence NM_001111316 within exon 29 of 33 total exons. The mutated nucleotide is indicated in red. The mutation results in a methionine to lysine substitution at position 1,021 (M1021K) in variant 1 of the PTPRC protein. (J:265143)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 188 strains or lines available

References

• Original: J:265143 Zhong X, et al., Mutagenetix entry for Half_measure. MGI Direct Data Submission. 2018
• All: 1 reference(s)