Dclre1c^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dclre1c^M2Btlr
• Name: DNA cross-link repair 1C; mutation 2, Bruce Beutler
• MGI ID: MGI:6199679
• Synonyms: Chairy
• Gene: Dclre1c Location: Chr2:3425168-3465167 bp, + strand Genetic Position: Chr2, 1.93 cM
• Alliance: Dclre1c^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 3,452,863 (v38) on chromosome 2, or base pair 28,802 in the GenBank genomic region NC_000068. The mutation corresponds to residue 1,259 in the mRNA sequences NM_146114 within exon 14 of 14 total exons. The mutation results in a leucine to proline substitution at position 391 (L391P) in the Artemis protein. (J:265131)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclre1c Mutation: 30 strains or lines available

References

• Original: J:265131 Zhong X, et al., Mutagenetix entry for Chairy. MGI Direct Data Submission. 2018
• All: 1 reference(s)