Trp53^em2Mvw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trp53^em2Mvw
• Name: transformation related protein 53; endonuclease-mediated mutation 2, Michael Wiles
• MGI ID: MGI:6199168
• Synonyms: Trp53 delta176
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^em2Mvw page

Mutation origin

• Strain of Origin: SJL/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Microinjection of CRISPR/Cas9 and guide sequences into fertilized oocytes yielded this 176 base pair deletion, which begins in the early part of exon 4 (GAGTGCAGGAGCTCCT), eliminates nearly the entire exon, and is predicted to cause a frameshift. (J:101977)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)