Ly6atm2.1(cre/Esr1*)Jmol
Targeted Allele Detail
|
Symbol: |
Ly6atm2.1(cre/Esr1*)Jmol |
Name: |
lymphocyte antigen 6 family member A; targeted mutation 2.1, Jeffery D Molkentin |
MGI ID: |
MGI:6198591 |
Synonyms: |
Ly6aMerCreMer |
Gene: |
Ly6a Location: Chr15:74866726-74869880 bp, - strand Genetic Position: Chr15, 34.29 cM
|
Alliance: |
Ly6atm2.1(cre/Esr1*)Jmol page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:264764
|
Parent Cell Line: |
W4 (ES Cell)
|
Strain of Origin: |
129S6/SvEvTac
|
|
Allele Type: |
|
Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Ly6atm2.1(cre/Esr1*)Jmol expression driven by
1 gene
Knock-in expression driven by:
|
|
|
Mutation details: A cDNA encoding a MerCreMer fusion protein and an FRT-flanked neomycin cassette were recombined in-frame with the Ly6a ATG start codon (exon 2) via homologous recombination in embryonic stem (ES) cells. The MerCreMer double fusion protein incorporates a cre recombinase cDNA sequence flanked by mutated murine estrogen receptor (mer) ligand binding domains (amino acids 281-599, G525R). Resultant mice were crossed with Flpe mice to delete the neomycin cassette. Expression of Ly6a is eliminated in the targeted allele.
(J:264764)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Ly6a
(mouse)
|
|
|
|
|
Original: |
J:264764 Vagnozzi RJ, et al., Genetic Lineage Tracing of Sca-1(+) Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. 2018 Jul 10; |
All: |
1 reference(s) |
|