Trim28^em1Hzo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim28^em1Hzo
• Name: tripartite motif-containing 28; endonuclease-mediated mutation 1, Huda Y Zoghbi
• MGI ID: MGI:6198016
• Synonyms: Trim28^E3MT
• Gene: Trim28 Location: Chr7:12758079-12764959 bp, + strand Genetic Position: Chr7, 7.73 cM, cytoband A2
• Alliance: Trim28^em1Hzo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination introduced C66A, C69A and R72G mutations in the RING domain. The resulting mutant protein is highly unstable. (J:264191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim28 Mutation: 35 strains or lines available

References

• Original: J:264191 Rousseaux MW, et al., Depleting Trim28 in adult mice is well tolerated and reduces levels of alpha-synuclein and tau. Elife. 2018 Jun 4;7:e36768
• All: 1 reference(s)