Ptprc^tm1.1Dats
Targeted Allele Detail

Summary

• Symbol: Ptprc^tm1.1Dats
• Name: protein tyrosine phosphatase receptor type C; targeted mutation 1.1, David Scadden
• MGI ID: MGI:6197900
• Synonyms: CD45.1^STEM
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^tm1.1Dats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236940
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector is designed to introduce a single A to G point mutation in base pair 904 of exon 7, and a FRT site flanked NEO cassette downstream of exon 7 of the gene. The point mutation results in a lysine to glutamic acid (K302 to E302). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:236940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 211 strains or lines available

References

• Original: J:236940 Mercier FE, et al., Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016 Jun 14;6(6):985-92
• All: 2 reference(s)