Ppargc1a^tm1.1Chang
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm1.1Chang
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1.1, Ji Suk Chang
• MGI ID: MGI:6197778
• Synonyms: NT-PGC-1alpha^-
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm1.1Chang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A targeting vector replaces exons 6 and 7 with a fusion of exons 6 and 7 and a floxed neo cassette. Cre mediated recombination removed the neo cassette. This mutation prevents expression of the shorter isoforms of the gene. qPCR analysis confirmed the absence of the N-terminal splice variant and the presence of the long isoform in tissues from homozygous mice. (J:264627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 47 strains or lines available

References

• Original: J:264627 Kim J, et al., NT-PGC-1alpha deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo. J Lipid Res. 2018 Sep;59(9):1660-1670
• All: 2 reference(s)