Gdf15^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gdf15^tm1Lex
• Name: growth differentiation factor 15; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:6197064
• Gene: Gdf15 Location: Chr8:71082043-71085106 bp, - strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Gdf15^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A selection cassette replaced exon and intron sequence from the ATG start site to the stop site via homologous recombination. (J:166124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf15 Mutation: 26 strains or lines available

References

• Original: J:264354 Tran T, et al., GDF15 deficiency promotes high fat diet-induced obesity in mice. PLoS One. 2018;13(8):e0201584
• All: 2 reference(s)