Slc30a8^tm2.1Vlcg
Targeted Allele Detail

Summary

• Symbol: Slc30a8^tm2.1Vlcg
• Name: solute carrier family 30 (zinc transporter), member 8; targeted mutation 2.1, Velocigene
• MGI ID: MGI:6197057
• Gene: Slc30a8 Location: Chr15:52158949-52199194 bp, + strand Genetic Position: Chr15, 19.88 cM
• Alliance: Slc30a8^tm2.1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a lacZ gene and a self-excising neo cassette via homologous recombination. (J:264368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc30a8 Mutation: 25 strains or lines available

References

• Original: J:264368 Kleiner S, et al., Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649
• All: 1 reference(s)