Mefv^em1Fsha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mefv^em1Fsha
• Name: Mediterranean fever; endonuclease-mediated mutation 1, Feng Shao
• MGI ID: MGI:6196622
• Gene: Mefv Location: Chr16:3525082-3535961 bp, - strand Genetic Position: Chr16, 2.18 cM
• Alliance: Mefv^em1Fsha page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• TALEN-based genome editing was used to introduce an 8 bp deletion in exon 2. (J:264437)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mefv Mutation: 45 strains or lines available

References

• Original: J:264437 Xu H, et al., Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature. 2014 Sep 11;513(7517):237-41
• All: 1 reference(s)