Mlxipl^tm1.1Liang
Targeted Allele Detail

Summary

• Symbol: Mlxipl^tm1.1Liang
• Name: MLX interacting protein-like; targeted mutation 1.1, Guosheng Liang
• MGI ID: MGI:6196060
• Synonyms: Chrebp^f
• Gene: Mlxipl Location: Chr5:135118744-135167236 bp, + strand Genetic Position: Chr5, 75.0 cM
• Alliance: Mlxipl^tm1.1Liang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262508
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site upstream of exon 9 and a loxP site followed by an FRT-site flanked PGK-neo-pA selection cassette downstream of exon 15. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 9 through 15 floxed. (J:262508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlxipl Mutation: 54 strains or lines available

Notes

ES cell line = LR-2 albino C57BL/6N

References

• Original: J:262508 Linden AG, et al., Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice. J Lipid Res. 2018 Mar;59(3):475-487
• All: 4 reference(s)