Siglece^tm1.2Avrk
Targeted Allele Detail

Summary

• Symbol: Siglece^tm1.2Avrk
• Name: sialic acid binding Ig-like lectin E; targeted mutation 1.2, Ajit Varki
• MGI ID: MGI:6195821
• Synonyms: EKO
• Gene: Siglece Location: Chr7:43300494-43309585 bp, - strand Genetic Position: Chr7, 28.25 cM, cytoband B2
• Alliance: Siglece^tm1.2Avrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274372
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector contains from 5' to 3' a loxP site, cDNA encoding the transmembrane and cytosolic domains of human SIGLEC16 gene, a human growth hormone polyadenylation sequence and an FRT-site flanked neo cassette inserted into exon 4. A second loxP site is inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 4-5. (J:274372)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Siglece Mutation: 28 strains or lines available

References

• Original: J:274372 Uchiyama S, et al., Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7465-7470
• All: 3 reference(s)