Amer1^tm1.2Asc
Targeted Allele Detail

Summary

• Symbol: Amer1^tm1.2Asc
• Name: APC membrane recruitment 1; targeted mutation 1.2, Andreas Schedl
• MGI ID: MGI:6195740
• Synonyms: Wtx^KO
• Gene: Amer1 Location: ChrX:94463919-94488446 bp, - strand Genetic Position: ChrX, 41.99 cM
• Alliance: Amer1^tm1.2Asc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262799
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 337 bp upstream of exon 2 and 1674 bp downstream of the first codon. Cre-mediated recombination removed the floxed neomycin resistance cassette and most of the coding sequence in exon 2. (J:262799)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amer1 Mutation: 2 strains or lines available

References

• Original: J:262799 Comai G, et al., Genetic and Molecular Insights Into Genotype-Phenotype Relationships in Osteopathia Striata With Cranial Sclerosis (OSCS) Through the Analysis of Novel Mouse Wtx Mutant Alleles. J Bone Miner Res. 2018 May;33(5):875-887
• All: 1 reference(s)