Hsf1^tm2.1Miv
Targeted Allele Detail

Summary

• Symbol: Hsf1^tm2.1Miv
• Name: heat shock factor 1; targeted mutation 2.1, Nahid F Mivechi
• MGI ID: MGI:6195629
• Synonyms: hsf1^f
• Gene: Hsf1 Location: Chr15:76361562-76385355 bp, + strand Genetic Position: Chr15, 35.95 cM
• Alliance: Hsf1^tm2.1Miv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246345
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT-flanked neomycin gene with one loxP site at the distal end was inserted into intron 3 and the proximal loxP site was inserted into intron 1. Flp-mediated recombination removed the selection cassette leaving exons 2-3 floxed. (J:246345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsf1 Mutation: 24 strains or lines available

References

• Original: J:246345 Qiao A, et al., The transcriptional regulator of the chaperone response HSF1 controls hepatic bioenergetics and protein homeostasis. J Cell Biol. 2017 Mar 06;216(3):723-741
• All: 2 reference(s)