Col17a1^{tm1.1(COL17A1)Zliu}
Targeted Allele Detail

Summary

• Symbol: Col17a1^{tm1.1(COL17A1)Zliu}
• Name: collagen, type XVII, alpha 1; targeted mutation 1.1, Zhi Liu
• MGI ID: MGI:6195004
• Synonyms: BP180NC16A, NC16A+
• Gene: Col17a1 Location: Chr19:47634783-47680460 bp, - strand Genetic Position: Chr19, 40.07 cM
• Alliance: Col17a1^{tm1.1(COL17A1)Zliu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mouse NC14A domain (exons 17-18) was replaced with the human NC16A counterpart encoded by exons 18 and 19, which were flanked by loxP sites. A FRT-flanked neo cassette was removed via flp-mediated recombination. RT-PCR and immunofluorescence confirmed expression of the human domain. (J:261781)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col17a1 Mutation: 49 strains or lines available

References

• Original: J:261781 Liu Z, et al., Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model. J Autoimmun. 2008 Dec;31(4):331-8
• All: 4 reference(s)