Tg(GFAP-ATXN7*10Q)2791Als
Transgene Detail
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Symbol: |
Tg(GFAP-ATXN7*10Q)2791Als |
Name: |
transgene insertion 2791, Albert La Spada |
MGI ID: |
MGI:6194623 |
Synonyms: |
Gfa2-SCA7-10Q |
Transgene: |
Tg(GFAP-ATXN7*10Q)2791Als Location: unknown
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Alliance: |
Tg(GFAP-ATXN7*10Q)2791Als page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(GFAP-ATXN7*10Q)2791Als expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ATXN7 (6314) |
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Mutation details: A 2.2-kb human glial fibrillary acidic protein fragment of the promotor region drives the expression of a flag and c-myc tagged human ataxin-7 cDNA bearing 10 glutamines. Western blot analysis confirmed expression of the transgene. Immunostaining confirmed that expression is restricted to regions of the cerebellum in which Bergmann glia reside and is probably cytoplasmic or perinuclear. This is a moderate expressing line.
(J:113150)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:113150 Custer SK, et al., Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 2006 Oct;9(10):1302-11 |
All: |
1 reference(s) |
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