Fbn2^timon
Spontaneous Allele Detail

Summary

• Symbol: Fbn2^timon
• Name: fibrillin 2; timon
• MGI ID: MGI:6194346
• Gene: Fbn2 Location: Chr18:58141689-58343200 bp, - strand Genetic Position: Chr18, 32.15 cM, cytoband D-E1
• Alliance: Fbn2^timon page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: Owing to a genomic deletion (chromosome 18: 58,012,626-58,014,322 GRCm38) that includes exon 63, transcripts from this allele lack exon 63 (of 65 total exons), and improperly splice exon 62 to exon 64, which leads to a frameshift and premature termination. (J:263533)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn2 Mutation: 142 strains or lines available

References

• Original: J:263533 Geister KA, et al., Optimizing Genomic Methods for Mapping and Identification of Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice. G3 (Bethesda). 2018 Feb 2;8(2):401-409
• All: 1 reference(s)