Aicda^em1Cml
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aicda^em1Cml
• Name: activation-induced cytidine deaminase; endonuclease-mediated mutation 1, Caroline Leeth
• MGI ID: MGI:6194206
• Synonyms: Line 1
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^em1Cml page

Mutation origin

• Strain of Origin: NOD/ShiLtDvs

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to introduce a 2bp deletion (position 89-90 of the gene) and a 309bp insertion into exon 1. The mutation is in the 5'-UTR and generates a null allele. (J:263862)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:263862 Ratiu JJ, et al., Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. 2017 Jun 01;198(11):4255-4267
• All: 2 reference(s)