Tg(TREM2)1Xwy
Transgene Detail
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Symbol: |
Tg(TREM2)1Xwy |
Name: |
transgene insertion 1, X William Yang |
MGI ID: |
MGI:6194033 |
Transgene: |
Tg(TREM2)1Xwy Location: unknown
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Alliance: |
Tg(TREM2)1Xwy page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(TREM2)1Xwy expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TREM2 (54209) |
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Mutation details: The human bacterial artificial chromosome (BAC) RP11-237K15 containing the entire TREM2 gene with adjacent 50 kb + flanking regions, and the TREML1, TREML2, and TREML4 genes, was modified by deleting the TREML1, TREML2, and TREML4 genes. The modifications to the BAC were as follows: exons 1 through 3 and the proximal promoter region (most of the protein coding sequence) were deleted in TREML4; the proximal promoter region as well as exons 1, 2, 5 and 6 (80% of the protein coding sequence) were deleted in TREML1; and exons 2 and 3 of the TREML2 gene were deleted (resulting in a frameshift with early stop codon in exon 4). Founder line A, which carries 1 or 2 copies of the transgene (transgene copy number estimated by genomic qPCR) was subsequently established.
(J:262250)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:262250 Lee CYD, et al., Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018 Mar 7;97(5):1032-1048.e5 |
All: |
1 reference(s) |
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