Fap^tm1.1Gne
Targeted Allele Detail

Summary

• Symbol: Fap^tm1.1Gne
• Name: fibroblast activation protein; targeted mutation 1.1, Genentech
• MGI ID: MGI:6193814
• Gene: Fap Location: Chr2:62331280-62404365 bp, - strand Genetic Position: Chr2, 35.85 cM
• Alliance: Fap^tm1.1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263764
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LoxP site flanked neomycin resistance gene cassette was inserted to replace exons 1 and 2. The neo cassette was subsequently removed through cre-mediated recombination. (J:263764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fap Mutation: 59 strains or lines available

References

• Original: J:263764 Dunshee DR, et al., Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21. J Biol Chem. 2016 Mar 11;291(11):5986-96
• All: 2 reference(s)