Tg(KRT14-COL5A1)#Flru
Transgene Detail

Summary

• Symbol: Tg(KRT14-COL5A1)#Flru
• Name: transgene insertion, Florence Ruggiero
• MGI ID: MGI:6192700
• Synonyms: K14-COL5A1
• Transgene: Tg(KRT14-COL5A1)#Flru Location: unknown
• Alliance: Tg(KRT14-COL5A1)#Flru page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-COL5A1)#Flru expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COL5A1 (1289)

  Col5a1

  (MGI:88457)

  human promoter and human gene

• Mutation details: The transgene comprises the following elements: the human keratin 14 promoter up to the translation start site, human collagen type V alpha 1 cDNA, and KRT14 3' UTR sequence including poly(A) signal. The construct was microinjected into male pronuclei of fertilized oocytes. Immunoblots and RT-PCR confirmed this transgene drives the expression of COL5A1 in the epidermis. (J:189446)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189446 Bonod-Bidaud C, et al., In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol. 2012 Jul;132(7):1841-9
• All: 2 reference(s)