Sema4d^em1Tshu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sema4d^em1Tshu
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; endonuclease-mediated mutation 1, Hai Qi
• MGI ID: MGI:6192542
• Gene: Sema4d Location: Chr13:51839565-51947783 bp, - strand Genetic Position: Chr13, 26.16 cM, cytoband B1
• Alliance: Sema4d^em1Tshu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a single nucleotide that replaces the seventh codon with a premature stop codon. Flow cytometry confirmed the absence of protein expression. (J:254360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema4d Mutation: 85 strains or lines available

References

• Original: J:254360 Yan H, et al., Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center. Cell Rep. 2017 May 2;19(5):995-1007
• All: 1 reference(s)