Fgf23^tm2.1Kew
Targeted Allele Detail

Summary

• Symbol: Fgf23^tm2.1Kew
• Name: fibroblast growth factor 23; targeted mutation 2.1, Kenneth E White
• MGI ID: MGI:6192524
• Synonyms: Flox-Fgf23
• Gene: Fgf23 Location: Chr6:127049865-127058371 bp, + strand Genetic Position: Chr6, 61.92 cM
• Alliance: Fgf23^tm2.1Kew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263740
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted in intron 1. (J:263740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf23 Mutation: 19 strains or lines available

References

• Original: J:263740 Clinkenbeard EL, et al., Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia. J Bone Miner Res. 2016 Jun;31(6):1247-57
• All: 4 reference(s)