Gt(ROSA)26Sor^{tm2(CAG-KCNJ2/mCherry)Fmr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-KCNJ2/mCherry)Fmr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Filippo M Rijli
• MGI ID: MGI:6191641
• Synonyms: R26^Kir, R26^{Kir2.1-mCherry}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-KCNJ2/mCherry)Fmr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245007
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed STOP cassette, human Kir2.1 coding sequence fused to the mCherry reporter gene, a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability) and polyadenylation sequence. (J:245007)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:245007 Moreno-Juan V, et al., Prenatal thalamic waves regulate cortical area size prior to sensory processing. Nat Commun. 2017 Feb 03;8:14172
• All: 8 reference(s)