Pcsk9^tm1.1Mrl
Targeted Allele Detail

Summary

• Symbol: Pcsk9^tm1.1Mrl
• Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1.1, Merck Research Laboratory
• MGI ID: MGI:6191609
• Synonyms: Pcsk9^flox, Pcsk9^tm1.1Xen
• Gene: Pcsk9 Location: Chr4:106299531-106321522 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Pcsk9^tm1.1Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245021
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed. Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette. (J:245021)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcsk9 Mutation: 44 strains or lines available

References

• Original: J:245021 Haas ME, et al., The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 05;134(1):61-72
• All: 4 reference(s)