Adamts3^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Adamts3^tm1.2Itl
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 3; targeted mutation 1.2, inGenious Targeting Laboratory
• MGI ID: MGI:6189557
• Gene: Adamts3 Location: Chr5:89824946-90031193 bp, - strand Genetic Position: Chr5, 44.32 cM
• Alliance: Adamts3^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245044
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Inversion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 8 through 10. (J:245044)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts3 Mutation: 66 strains or lines available

References

• Original: J:245044 Janssen L, et al., ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016 Jan;19(1):53-65
• All: 1 reference(s)