Lmx1a^tm1.1Dkwu
Targeted Allele Detail

Summary

• Symbol: Lmx1a^tm1.1Dkwu
• Name: LIM homeobox transcription factor 1 alpha; targeted mutation 1.1, Doris Wu
• MGI ID: MGI:6188985
• Synonyms: Lmx1a^lox
• Gene: Lmx1a Location: Chr1:167516806-167676310 bp, + strand Genetic Position: Chr1, 75.08 cM
• Alliance: Lmx1a^tm1.1Dkwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262601
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 2. (J:262601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmx1a Mutation: 23 strains or lines available

References

• Original: J:262601 Huang Y, et al., Reciprocal Negative Regulation Between Lmx1a and Lmo4 Is Required for Inner Ear Formation. J Neurosci. 2018 Jun 6;38(23):5429-5440
• All: 1 reference(s)