Ctnna3^tm1Fvr
Targeted Allele Detail

Summary

• Symbol: Ctnna3^tm1Fvr
• Name: catenin alpha 3; targeted mutation 1, Frans van Roy
• MGI ID: MGI:6188300
• Synonyms: alphaT-catenin^fl
• Gene: Ctnna3 Location: Chr10:63265877-64839446 bp, + strand Genetic Position: Chr10, 32.57 cM
• Alliance: Ctnna3^tm1Fvr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197814
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. (J:197814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnna3 Mutation: 45 strains or lines available

References

• Original: J:197814 Li J, et al., Loss of alphaT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci. 2012 Feb 15;125(Pt 4):1058-67
• All: 5 reference(s)