Tg(Ins2-IAPP)25-3Rpa
Transgene Detail

Summary

• Symbol: Tg(Ins2-IAPP)25-3Rpa
• Name: transgene insertion 25-3, Richard D Palmiter
• MGI ID: MGI:6188081
• Synonyms: Tg(RIP-hIAPP)CStka
• Transgene: Tg(Ins2-IAPP)25-3Rpa Location: unknown
• Alliance: Tg(Ins2-IAPP)25-3Rpa page

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-IAPP)25-3Rpa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IAPP (3375)

  Iapp	(MGI:96382)

• Tg(Ins2-IAPP)25-3Rpa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The transgene was comprised of a 600-bp rat insulin II promoter (RIP) fragment and the 3-UTR of the mouse MHC Ea-II gene, including the polyadenylation sequence, flanking a 676-bp Sma/Bgl I fragment of the human IAPP cDNA, containing the entire coding sequence of the gene. Only one line, 25-3 was studied further. (J:263024)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:263024 D'Alessio DA, et al., Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. Diabetes. 1994 Dec;43(12):1457-61
• All: 23 reference(s)