Cdh8^tm2Mta
Targeted Allele Detail

Summary

• Symbol: Cdh8^tm2Mta
• Name: cadherin 8; targeted mutation 2, Masatoshi Takeichi
• MGI ID: MGI:6188006
• Synonyms: Cad8^-, Cdh8^LacZ
• Gene: Cdh8 Location: Chr8:99751103-100143103 bp, - strand Genetic Position: Chr8, 49.4 cM
• Alliance: Cdh8^tm2Mta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: The sequences encoding the first 83 amino acids were replaced by a taulacZ or gaplacZ and floxed neo cassette into exon 2. Western blot confirmed absence of protein in mutant spinal cord. (J:120130)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh8 Mutation: 53 strains or lines available

Notes

The version of this allele that does not contain the neomycin selection cassette, Cdh8^tm1Mta, has been analyzed.

References

• Original: J:120130 Suzuki SC, et al., Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 2007 Mar 28;27(13):3466-76
• All: 2 reference(s)