Tg(RHO)ETpd
Transgene Detail

Summary

• Symbol: Tg(RHO)ETpd
• Name: transgene insertion E, Thaddeus P Dryja
• MGI ID: MGI:6187991
• Synonyms: NHR-E
• Transgene: Tg(RHO)ETpd Location: unknown
• Alliance: Tg(RHO)ETpd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene comprises a 15.9-kb human genomic DNA fragment containing the wild-type allele of the rhodopsin gene with 4.8 kb of DNA upstream of the start codon and 6.2 kb of DNA downstream of the termination codon. Densitometric analysis of transgene-derived human and endogenous mouse rhodopsin mRNA-derived bands on autoradiographs of polyacrylamide gel-separated [alpha-³²P]-dCTP-labeled RT-PCR products of retinal mRNA from heterozygous transgenic mice revealed a human:mouse transcript ratio of 1:1. (J:76722)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76722 Olsson JE, et al., Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov;9(5):815-30
• All: 3 reference(s)