Nphs1^tm1.1Pgarg
Targeted Allele Detail

Summary

• Symbol: Nphs1^tm1.1Pgarg
• Name: nephrosis 1, nephrin; targeted mutation 1.1, Puneet Garg
• MGI ID: MGI:6187990
• Synonyms: Nphs1^fl
• Gene: Nphs1 Location: Chr7:30157740-30186648 bp, + strand Genetic Position: Chr7, 18.36 cM, cytoband A3
• Alliance: Nphs1^tm1.1Pgarg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262952
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:262952)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nphs1 Mutation: 70 strains or lines available

References

• Original: J:262952 Verma R, et al., Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus. PLoS One. 2018;13(6):e0198013
• All: 2 reference(s)