Plcz1^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcz1^em1Osb
• Name: phospholipase C, zeta 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6187986
• Synonyms: Plcz1^em1Maik
• Gene: Plcz1 Location: Chr6:139935399-139987183 bp, - strand Genetic Position: Chr6, 69.77 cM, cytoband G1
• Alliance: Plcz1^em1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258193
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The molecular lesion is a 50.8 kbp deletion of all the coding exons (exons 2-14). Absence of the encoded protein was confirmed by western blotting analysis on extracts from homozygous mice. (J:258193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plcz1 Mutation: 56 strains or lines available

References

• Original: J:258193 Nozawa K, et al., Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice. Sci Rep. 2018 Jan 22;8(1):1315
• All: 2 reference(s)