Sik3^em5Iiis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sik3^em5Iiis
• Name: SIK family kinase 3; endonuclease-mediated mutation 5, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:6164771
• Synonyms: FLAG-Sik3S551A
• Gene: Sik3 Location: Chr9:45924118-46135492 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sik3^em5Iiis page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A well-conserved PKA phosphorylated site, 551 Serine residue, is substituted with alanine. FLAG sequence is inserted in the N-terminus. (J:266567)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik3 Mutation: 71 strains or lines available

References

• Original: J:266567 Honda T, et al., A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463
• All: 1 reference(s)