Scx^em13Shuk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scx^em13Shuk
• Name: scleraxis scleraxis bHLH transcription factor; endonuclease-mediated mutation 13, Chisa Shukunami
• MGI ID: MGI:6164649
• Gene: Scx Location: Chr15:76341652-76343658 bp, + strand Genetic Position: Chr15, 35.92 cM
• Alliance: Scx^em13Shuk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Talen mediated mutation resulted in an 11bp deletion in exon 1 producing both a frameshift and premature stop codons downstream. This mutation was found in founder 13. (J:262633)

Expression

In Mice Carrying this Mutation:

39 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scx Mutation: 12 strains or lines available

References

• Original: J:262633 Shukunami C, et al., Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Sci Rep. 2018 Feb 16;8(1):3155
• All: 1 reference(s)